ViroBiome Safety

ViroBiome™ Safety (HTR1)

Core Functional Barrier Technology

For Next Generation Augmented Hygiene

A patented plant-derived surface protection technology for exposed biological interfaces and functional hygiene systems.

Executive Overview

ViroBiome™ Safety, HTR1™, is the foundational functional barrier technology of the ViroBiome™ Augmented Hygiene platform.

It is based on a patented, non-proteinic, plant-derived complex of α and β amyrins from Protium heptaphyllum, designed to support localized surface protection, interface balance and biological resilience.

Patent status

Patented technology
European patent granted
Non-proteinic plant-derived functional active

ViroBiome™ Safety is not positioned as a disinfectant, preservative or aggressive elimination technology.

It is positioned as a localized surface protection technology enabling biologically active hygiene systems compatible with microbiome preservation, non-systemic action and functional interface support.

Why Safety Matters Now

Hygiene is entering a new phase.

Conventional hygiene has historically focused on cleansing, removal and elimination.

This approach remains useful, but it is no longer sufficient for high-density urban environments, aging populations and repeated contact exposure.

Skin, mucosa and fragile epithelial zones are increasingly challenged by:

• particulate matter
• environmental stress
• repeated contact
• friction
• pollution
• biological surface imbalance
• weakened barrier resilience

ViroBiome™ Safety addresses this transition through a complementary hygiene logic.

Protect. Reinforce. Preserve.

Macro Context

Urbanization

High-density environments increase:

• repeated surface interaction
• particulate and pollutant exposure
• environmental stress
• daily pressure on exposed biological interfaces
• contact between skin, mucosa and external surfaces

Population Aging

Aging tissues may present:

• weaker barrier integrity
• slower recovery capacity
• altered surface balance
• increased sensitivity to environmental stress
• greater vulnerability to friction and repeated exposure

Climate Warming

Climate warming adds a third systemic pressure on exposed biological interfaces.

Rising temperatures, heat waves, air pollution peaks, wildfire particles, longer pollen seasons and increased aeroallergen exposure may intensify daily stress on skin, mucosa and fragile epithelial zones.

Climate warming can contribute to:

• increased heat stress on exposed tissues
• higher oxidative pressure from pollution and wildfire particles
• longer and more intense allergen exposure
• greater skin and mucosal sensitivity during extreme weather events
• increased dehydration pressure on the epidermal barrier
• more frequent interaction between pollution, humidity, heat and biological surface imbalance

Together, urbanization, aging and climate warming create a structural need for hygiene technologies that do more than clean.

They must help exposed interfaces remain resilient in environments that are hotter, denser, more polluted and biologically more unstable.

What Is ViroBiome™ Safety?

ViroBiome™ Safety, HTR1™, is a standardized plant-derived AMY complex designed for localized surface action.

It is based on α and β amyrins, naturally occurring pentacyclic triterpenes identified in plant resins, especially within the Burseraceae family and the Protium genus.

The technology is designed to support:

• localized surface protection
• functional barrier reinforcement
• biological interface balance
• microbiome-compatible hygiene
• non-systemic surface action
• integration into advanced hygiene materials
• compatibility with daily-use hygiene formats

ViroBiome™ Safety is the technological backbone of the ViroBiome™ platform.

It can be used alone or combined with complementary bioactive modules.

Scientific & Functional Foundation

Plant-Derived Surface Active

HTR1™ is a non-proteinic botanical complex based on α and β amyrins.

These naturally occurring triterpenes provide a differentiated plant-derived active platform for functional hygiene applications.

Localized Barrier Support

ViroBiome™ Safety is designed to act locally at exposed surfaces.

The objective is to support the formation of a functional interface layer that helps reduce direct interaction between external stressors and biological surfaces.

Ex Vivo Barrier Evidence

In an ex vivo human skin explant model exposed to particulate matter, a Spray SV formula containing 2.5% HTR1 was evaluated through IL-6 measurement after application.

This dataset supports a localized barrier-effect positioning against particulate environmental stress.

The appropriate wording is “functional surface barrier effect” or “localized interface protection”.

Avoid wording such as medical protection, disease prevention or therapeutic activity.

Microbiome-Compatible Hygiene

ViroBiome™ Safety is not designed as a broad elimination technology.

It is positioned as an augmentation layer for hygiene systems that aim to preserve biological surface balance while reinforcing exposed interfaces.

Core Functional Benefits

Localized Functional Barrier

Supports exposed surfaces against environmental and contact-related stressors.

Non-Systemic Surface Action

Designed for local action at the interface, without systemic positioning.

Plant-Derived Technology

Based on a patented botanical AMY complex from Protium heptaphyllum.

Microbiome-Compatible Positioning

Supports a more balanced hygiene model that does not rely on aggressive elimination.

Platform Backbone

Serves as the core functional layer of ViroBiome™ PROTECT, ViroBiome™ SHIELD and future compartmentalized bioactive hygiene architectures.

Industrial Scalability

Designed for integration into formulations, coatings, treated supports and functional hygiene materials.

Industrial Integration Framework

Technology format

Standardized lipophilic AMY complex.

Indicative inclusion level

2.5% in final formulation, to be adapted according to the product category, regulatory pathway, exposure duration and safety assessment.

Compatible formats

• sprays
• gels
• emulsions
• lotions
• surface coatings
• treated hygiene supports
• wipe-off systems
• selected skin-contact applications
• functional nonwoven substrates
• respiratory-adjacent hygiene formats
• intimate care formulations, subject to dedicated validation

Industrial spray coverage

Approximately 1 mL for 400 cm².

Designed for scalable integration into automated coating, spraying and formulation workflows without requiring major structural modification.

Platform Architecture

ViroBiome™ Safety is the foundational surface protection layer of the ViroBiome™ platform.

It can be combined with complementary bioactive modules to create differentiated product families.

ViroBiome™ Safety alone

Core functional barrier support and localized surface protection.

ViroBiome™ PROTECT

HTR1™ plus Rapeseed Peptides.

Controlled short-contact and rinse-off applications only.

This module should not be positioned for prolonged dermal or mucosal contact without dedicated systemic exposure and cardiovascular safety assessment.

ViroBiome™ SHIELD

HTR1™ plus Rapeseed Ceramides.

Lipid barrier reinforcement, microbiome-compatible comfort and exposed interface resilience.

More suitable for longer-contact hygiene, skin comfort, nonwovens, tissues, wipes and barrier-oriented applications.

Advanced Surface Architecture

ViroBiome™ Safety can also be integrated into advanced compartmentalized surface architectures.

These architectures are designed to support:

• localized bioactive deposition
• controlled migration
• enhanced retention
• differentiated release
• separation of functional layers
• compatibility with next generation hygiene materials

This approach connects botanical surface protection with industrial material design.

It is particularly relevant for functional nonwovens, treated hygiene substrates, protective tissue technology and bioactive surface coatings.

Priority Application Segments

Functional Hygiene Systems

Localized surface support for next generation hygiene products.

Functional Nonwovens

Bioactive coating and controlled deposition systems for advanced hygiene materials.

Tissues & Wipes

Localized surface support for repeated contact applications.

Respiratory-Adjacent Hygiene

Interface protection concepts for nasal and perinasal exposure zones, subject to appropriate formulation and tolerance validation.

Intimate Hygiene

Microbiome-compatible hygiene formulations where local exposure and safety parameters are clearly defined.

Medical-Adjacent Materials

Barrier-oriented support technologies for non-therapeutic, hygiene-adjacent applications, subject to regulatory and safety assessment.

Strategic Positioning

Conventional Hygiene

Clean. Remove. Eliminate.

Augmented Hygiene

Protect. Reinforce. Preserve.

ViroBiome™ Safety, HTR1™, is the functional surface protection foundation enabling this transition.

It is not positioned as a disinfectant, preservative, medicinal treatment or broad elimination technology.

It is positioned as a next generation plant-derived functional barrier technology for augmented hygiene, exposed interfaces and advanced bioactive surface systems.

Scientific & IP Access

Detailed scientific documentation, experimental data, formulation guidance and intellectual property files are available under confidentiality agreement.

Contact
dominique.delarche@virobiome.com